Acute promyelocytic leukemia cases with nonreciprocal PML/RARa or RARa/PML fusion genes
نویسندگان
چکیده
منابع مشابه
Acute promyelocytic leukemia cases with nonreciprocal PML/RARa or RARa/PML fusion genes.
Tumor-associated chromosome translocations usually lead to the formation of two reciprocal fusion genes: one thought to be involved in the transformation process, the other the mechanical consequence of the translocation event. In the case of acute promyelocytic leukemia (APL) blasts, the 15;17 chromosome translocation generates the putatively transforming PML/RARa fusion gene and its reciproca...
متن کاملNew variant of acute promyelocytic leukemia with IRF2BP2–RARA fusion
We present an acute promyelocytic leukemia (APL) patient with two subtypes of IRF2BP2-RARA, in which the IRF2BP2 gene showed completely new breakpoints. Bone marrow examination revealed morphologic features indicative of APL. However, promyelocytic leukemia-RARA fusion was not detected. A paired-end mRNA sequencing followed by RT-PCR and direct sequencing revealed two types of fusion transcript...
متن کاملAcute myeloid leukemia and acute promyelocytic leukemia.
The therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as the influx of investigational approaches and novel...
متن کاملAcute myeloid leukemia pretreated with filgrastim mimicking acute promyelocytic leukemia.
A 66-year-old man with a history of hepatitis C virus and liver transplantation presented to the emergency department for shortness of breath. He had received weekly filgrastim for chronic neutropenia, and immediately before admission he had received 3 days of filgrastim and 1 day of pegfilgrastim. A hemogram showed a white blood cell count of 4.54 K/mL with 23% blastic cells. Emergent bone mar...
متن کاملtreatment of new cases of acute promyelocytic leukemia with arsenic trioxide
introduction: arsenic trioxide is effective and approved for treatment of relapsed or refractory apl cases to atra but its effects in new cases of apl is not clear and needs long term follow up to dis close the role of this drug in treatment of apl in combination with chemotherapy/atra or alone. material and methods: we studied 111cases of apl (94 new case and 17 relapsed) diagnosed by mor phol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1995
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v85.5.1169.1169